Poster

DIMENSIONI POSTER:

Altezza:105 cm

Larghezza: 95 cm

MND POSTER

 P.1      THE SMALL HEAT SHOCK PROTEIN B8 (HSPB8) REMOVES DIPEPTIDES PRODUCED IN C9ORF72-RELATED NEURODEGENERATIVE DISEASES

Cristofani R  (1), Crippa V (1), Cicardi ME (1), Rusmini P (1), Meroni M (1), Ferrari V (1), Tedesco B (1), Messi E (1), Piccolella M (1), Galbiati M (1), Carra S (2) and Poletti A (1)

(1) Sezione di Biomedicina ed Endocrinologia, Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy

(2) Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Università degli Studi di Modena e Reggio Emilia, Modena, Italy

 

P.2      N-TERMINAL MEDIATED OLIGOMERIZATION OF TDP-43 FAVORS INCORPORATION INTO STRESS GRANULES AND PREVENTS PATHOLOGICAL AGGREGATION

Foglieni C (1), Pérez-Berlanga M (2), Maniecka Z (2), Afroz T (2), Polymenidou M (2)

and Paganetti P (1)

(1) Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, Torricella-Taverne, Switzerland

(2) Institute of Molecular Life Sciences, University of Zurich

 

P.3      IDENTIFICATION AND CHARACTERIZATION OF RANT MODULATORS OF THE G4C2 EXPANSION

Licata NV (1), D’Agostino VG (1), Zucal C (1), Loffredo R (1), Cristofani R (2), Adami V (3), Pancher M (3), Quattrone A (4), Poletti A (2) and Provenzani A (1)

(1) Centre for Integrative Biology (CIBio), University of Trento, Trento, Italy

(2) Department of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Milano, Italy

(3) High-Throughput Screening Core Facility, Centre for Integrative Biology (CIBio), University of Trento, Trento, Italy

(4) Laboratory of Translational Genomic, Centre for Integrative Biology (CIBio), University of Trento, Trento, Italy

 

P.4      RELATION BETWEEN R-LOOPS AND STRESS GRANULES IN AMYOTROPHIC LATERAL SCLEROSIS

Giannini M (1,2), Sproviero D (1), Bordoni M (1,2), Diamanti L (2,3) Vinet J (1), Gagliardi S (1), Carra S (4), Pansarasa O (1) and Cereda Cristina (1)

(1) Genomic and post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy

(2) Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

(3) General Neurology, IRCCS Mondino Foundation, Pavia, Italy

(4) Department of Biomedical, Metabolical and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

 

P.5      CIRCULATING MUSCLE-DERIVED miR-206 LINKS ‘SKELETAL MUSCLE DYSFUNCTION-TO-HEART AUTONOMIC DENERVATION

Prando V (1,2), Bertoli S (2,3), Favaro G (2), Di Mauro V (4), Lo Verso F (2), Guescini M (5), Mariotti R (6), Catalucci D (4), Sandri M (2,3), Mongillo M (1,2,7) and Zaglia T (1,2,3)

(1) Department of Cardiac, Thoracic and Vascular Sciences, Padova, Italy

(2) Venetian Institute of Molecular Medicine (VIMM), Padova, Italy

(3) Department of Biomedical Sciences, University of Padova, Padova, Italy

(4) Humanitas Research Hospital, Milan, Italy

(5) Department of molecular Sciences, University of Urbino Carlo Bo, Urbino, Italy

(6) Department of Neurosciences, Biomedicine and Movement Science Verona, Italy

(7) CNR Institute of Neuroscience, Padova, Italy

 

P.6      STRESS RESPONSE IN MOTOR NEURONS – UNDERSTANDING ALS LINKED MOTOR NEURON DEGENERATION

Tripathy V, Marrone L and Sterneckert J

Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence at TU Dresden, Dresden, Germany

P.7      ACCUMULATION OF DAMAGED MITOCHONDRIA IN ALS PATIENTS’ PBMCS

Bordoni M (1,2), Pansarasa O (2), Fantini V (2), Leone R (3), Garau J (1,2), Diamanti L (1,4) and Cereda C (2)

(1) Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

(2) Center of Genomic and post-Genomic, IRCCS Mondino Foundation, Pavia, Italy

(3) Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

(4) Unit of General Neurology, IRCCS Mondino Foundation, Pavia, Italy

 

P.8      PATHOLOGICAL PROTEINS ARE TRANSPORTED BY EXTRACELLULAR VESICLES IN AMYOTROPHIC LATERAL SCLEROSIS

Sproviero D (1), La Salvia S (1), Giannini M (1,2), Crippa V (3), Gagliardi S (1), Diamanti L (2,4), Ceroni M (2,4), Pansarasa O (1), Poletti A (3) and Cereda C (1)

(1) Genomic and post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy

(2) Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

(3) Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy

(4) Division of General Neurology, IRCCS Mondino Foundation, Pavia, Italy

 

P.9      ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR IN AN IN VITRO MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

Maugeri G (1), D’Amico AG (2), Rasà DM (1), Morello G (3), La Cognata V (3), Sebastiano Cavallaro S (3) and D’Agata V (1)

(1) Section of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania

(2) Department of Human Science and Promotion of quality of Life, San Raffaele Open University of Rome, Italy

(3) Institute of Neurological Sciences, National Research Council, Catania, Italy

 

P.10     IDENTIFICATION OF NEW HSPB8 VARIANTS LINKED TO FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS

Crippa V (1), Tedesco B (1), Cicardi ME (1), Rusmini P (1), Cristofani R (1), Ferrari V (1), Vezzoli G (1), Meroni M (1), Messi E (1), Piccolella M (1), Galbiati M (1), Ticozzi N (2), Ratti A (2), Silani V (2), Carrà AD (3), Bigi I (3), Mediani L (3), Morelli FF (3), Carra S (3) and Poletti A (1)

(1) Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), “Department of Excellence 2018-2022”, Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy

(2) Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy

(3) Department of Biomedical, Metabolic and Neural Sciences, “Department of Excellence 2018-2022”, University of Modena and Reggio Emilia, Modena, Italy

 

P.11     ONCOGENES AND TRANSCRIPTION FACTORS LONG NON CODING RNA: NEW ACTORS IN ALS PATHOGENESIS

Gagliardi S (1), Zucca S (1), Pandini C (1,2), Sproviero D (1), Palmieri I (1,2), Pansarasa O (1), Garofalo M (2), Giallongo T. (3), Rey F (3), Carelli S (3), Di Giulio AM (3) and Cereda C (1).

(1) Genomic and post-Genomic Center, IRCCS Mondino Foundation, Pavia

(2) Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia

(3) Department of Health Sciences, Laboratory of Pharmacology, University of Milan

 

P.12     LONG NON CODING RNAS INVOLVED IN NEURONAL DEVELOPMENT SEEM TO PLAY A ROLE IN ALS PATHOLOGY

Rey F (1), Giallongo T (1), Marcuzzo S (2), Malacarne C (2), Bonanno S (2), Balsari A (1), Mantegazza R (2), Bernasconi P (2), Gorio A (1), Carelli S (1) (3) and Di Giulio AM (1) (3)

(1) Department of Health Sciences, University of Milan “Università degli Studi di Milano”, Milano, Italy

(2) Neurology IV – Neuroimmunology and Neuromuscular Diseases Unit, Fondazione Istituto Neurologico “Carlo Besta”, Milan, Italy

(3) Pediatric Clinical Research Center Fondazione “Romeo ed Enrica Invernizzi”, University of Milan “Università degli Studi di Milano”, Milan, Italy

 

P.13     DISTINCT FEATURES OF PLASMA EXTRACELLULAR VESICLES IN AMYOTROPHIC LATERAL SCLEROSIS PATIENTS

Pasetto L (1), D’agostino V (2), Quattrone A (2), Brunelli L (1), Pastorelli R (1), Corbelli A (1), Fiordaliso F (1), Calvo A (3), Chiò A (3), Corbo M (4), Lunetta C (5), Mora G (6), Basso M (2) and Bonetto V (1)

(1) IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy

(2) CIBIO – Università degli Studi di Trento, Trento, Italy

(3) Department of Neuroscience “Rita Levi Montalcini”, University of Torino, Torino, Italy

(4) Casa Cura Policlinico, Milano Italy

(5) NEuroMuscular Ominicentre (NEMO), Fondazione Serena Onlus, Milan Italy

(6) Maugeri IRCCS, Milano, Italy

 

P.14     FEATURES OF FRONTOTEMPORAL LOBAR DEGENERATION IN THE CYCLOPHILIN A KNOCK-OUT MICE

Pasetto L (1), Pozzi S (2), Micotti E (3), Carli M (3), Forloni G (3) and Bonetto V (1)

(1) Department of Biochemistry and Molecular Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

(2) CERVO Brain Research Center, Laval University, Québec City, Québec, Canada

(3) Department of Neuroscience, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

 

P.15     CYANOTOXINS EXPOSURE AND TDP-43 PHYSIOPATHOLOGY: A MOLECULAR STUDY

Sini P (1), Sanna S (1), Sarria M (2), Paladino S (3),  Solinas G (1), , Sotgiu MA (1), Padedda MB (2), Iaccarino C (1), Pierantoni MG (3), Lugliè A (2), Pignataro G (4) and Crosio C (1)

(1) Department of Biomedical Sciences, University of Sassari, Sassari, Italy

(2) Department of Architecture, Design and Urban planning, University of Sassari, Sassari, Italy

(3) Department of Molecular Medicine and Medical Biotechnology Federico II University of Naples, Naples, Italy

(4) Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University of Naples, Naples, Italy

 

P.16     MODULATION OF HISTAMINERGIC SIGNALING IN ALS

Apolloni S (1), Fabbrizio P (1,2), Amadio S (1), Napoli G (2), Verdile V (1), Morello G (3), Iemmolo R (3), Aronica E (4), Cavallaro S (3) and Volonté C (1,2)

(1) Experimental Neuroscience, Santa Lucia Foundation, Roma, Italy

(2) Institute of Cell Biology and Neurobiology, National Research Council, Roma, Italy

(3) Institute of Neurological Sciences, National Research Council, Catania, Italy

(4) Department of (Neuro) Pathology, Academic Medical Center, Amsterdam, The Netherlands

 

P.17     UNRAVELING THE ROLE OF NURR1 IN A MURINE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

Boido M (1), Valsecchi V (1), Guglielmotto M (1), Giochiglia N (1), Tamagno E (1) and Vercelli A (1)

(1) Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience, University of Turin, Turin, Italy

 

P.18     USING PATIENT-DERIVED ASTROCYTES TO UNRAVEL THE ROLE OF MISFOLDED SOD1 IN SALS CASES

Gatto N, Myszczynska M, Castelli L, Varcianna A, Stopford M, Hautbergue G, Shaw P J and Ferraiuolo L

Sheffield Institute for Translational Neuroscience, University of Sheffield (SITraN), Sheffield , UK

 

P.19     EFFECTS OF CYSTATHIONINE-B-SYNTHASE INHIBITOR DISEASE PROGRESSION IN SOD1-ALS MICE. IMPLICATIONS FOR ALS

Spalloni A (1), Greco V (2,3), Ciriminna G (1), Corasolla Carregari V (2,3), Pieroni L (4), Urbani A (2,3), Mercuri N B (5) and Longone P (1)

(1) Department of Experimental Neuroscience, Molecular Neurobiology Unit, Fondazione Santa Lucia-IRCCS, Rome, Italy

(2) Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy

(3) Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy

(4) Department of Experimental Neuroscience, Proteomics and Metabonomics Unit, Fondazione Santa Lucia-IRCCS, Rome, Italy

(5) Department of Experimental Neuroscience, Fondazione Santa-IRCCS, Rome Italy and Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy

 

P.20     COUNTERACTING ROLES OF MHCI AND CD8+ T CELLS IN THE PERIPHERAL AND CENTRAL NERVOUS SYSTEM OF ALS SOD1G93A MICE

Nardo G (1), Trolese MC (1), Verderio M (1), Mariani A (2), De Paola M (2), Riva N (3), Dina G (3), Panini N (4), Erba E (4), Quattrini (3) and Bendotti C (1)

(1) Laboratory of Molecular Neurobiology, Department of Neuroscience, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

(2) Laboratory of Analytical Biochemistry, Department of Environmental Health Sciences, IRCCS –Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

(3) Neuropathology Unit, Department of Neurology – INSPE- San Raffaele Scientific Institute, Dibit II, Milan, Italy

(4) Laboratory of Cancer Pharmacology Department of Oncology, Flow Cytometry Unit, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

 

P.21     MODULATION OF THE SOD1G93A ASTROCYTE PHENOTYPE BY EXPOSURE TO MESENCHYMAL STEM CELL-DERIVED EXOSOMES AND miRNAs

Provenzano F (1), Milanese M (1,2), Giunti D (3), Torazza C (1), Marini C (3), Parodi B (3), Balbi M (1), Usai C (4), Kerlero de Rosbo N (3), Uccelli A (2,3) and Bonanno G (1,2)

(1) Department of Pharmacy, University of Genoa, Genova, Italy

(2) Center of Excellence for Biomedical Research, University of Genoa, Genova, Italy

(3) DINOGMI, University of Genoa, Genova, Italy

(4) Institute of Biophysics, National Research Council, Genova, Italy

 

P.22     EFFECT OF C9ORF72 GENE DELETION ON THE PATHOLOGY PROGRESSION OF A FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL

Sironi F, De Giovanetti G, Tortarolo M, Cassarà J, Freschi M, Herrera V and Bendotti C

Molecular Neurobiology Lab, Department of Neuroscience, IRCCS – Mario Negri Institute, Milano, Italy

 

P.23     MGLUR5 ATTENUATES THE REACTIVE PHENOTYPE OF ASTROCYTES PREPARED FROM THE SPINAL CORD OF LATE SYMPTOMATIC MICE EXPRESSING THE SO1G93A POINT MUTATION

Torazza C (1), Milanese M (1,2), Gallia E (1), Provenzano F (1), Bonifacino T (1), Usai C (3) and Bonanno G (1,2)

(1) Department of Pharmacy, University of Genoa, Genoa, Italy

(2) Centre of Excellence for Biomedical Research, University of Genoa, Italy

(3) Institute of Biophysics, National Research Council, Genoa, Italy

 

P.24     ROLE OF CXCL13 IN THE PATHOPHYSIOLOGY OF ALS: STUDY IN TRANSGENIC SOD1G93A MICE

Trolese MC (1), Nardo G (1), Mariani A (2), De Paola M (2), Tortarolo M (1) and Bendotti C (1)

(1) Laboratory of Molecular Neurobiology, Department of Neuroscience, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

(2) Laboratory of Analytical Biochemistry, Department of Environmental Health Sciences, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

 

P.25     THE FUNCTION OF RELEASE-REGULATING PRESYNAPTIC GROUP I METABOTROPIC GLUTAMATE AUTORECEPTORS IS ENHANCED IN THE SPINAL CORD OF SOD1G93A MICE

Balbi M (1), Rebosio C (1), Bonifacino T (1), Milanese M (1,2), Raiteri L (1), Nadeem M (1), Usai C (3) and Bonanno G (1,2)

(1) Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genoa, Genova, Italy

(2) Centre of Excellence for Biomedical Research, University of Genoa, Genova, Italy

(3) Institute of Biophysics, National Research Council, Genova, Italy

 

P.26     ALTERATION OF GLUCOSE METABOLISM IN THE PRE- AND PERISYNAPTIC DISTRICTS OF THE SOD1G93A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

Ravera S (1), Bonifacino T (1), Bartolucci M (2), Torazza C (1), Provenzano F (1), Balbi M (1), Cortese K (3), Panfoli I (2) and Bonanno G (1,4)

(1) Department of Pharmacy, Unit of Pharmacology and Toxicology, University of Genoa, Genova, Italy

(2) Department of Pharmacy, Laboratory of Biochemistry, University of Genoa, Genova, Italy

(3) Department of Experimental Medicine, Unit of Human Anatomy, University of Genoa, Genova, Italy

(4) Center of Excellence for Biomedical Research, University of Genoa, Genova, Italy

 

P.27     REVEALING AXONAL TRANSLATOME DEFECTS IN CELLULAR MODELS OF ALS

Lauria F (1), Marchioretto M (1), Badaloni A (2), Croci L (2), Tebaldi T (4), Arnese R (1), Consalez GG (2,3) and Viero G (1)

(1) Institute of Biophysics, CNR Unit of Trento, Trento, Italy

(2) Division of Neuroscience; San Raffaele Scientific Institute, Milano, Italy

(3) Università Vita-Salute San Raffaele, Milano, Italy

(4) Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA

 

P.28     DEFECTIVE DIFFERENTIATION OF PRIMARY MYOCYTES IN AN ALS MOUSE MODEL

Peggion C (1), Massimino M L (2), Stella R (3), Nies K (1,4), Sorgato M C (1,2) and Bertoli A (1,5)

(1) Dept. of Biomedical Sciences, University of Padova, Italy

(2) Neuroscience Institute, CNR, University of Padova, Italy

(3) Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (PD), Italy

(4) University of Maastricht, The Netherlands

(5) Padova Neuroscience Center, University of Padova, Italy

 

P.29     UNREVEALING THE ROLE OF MUSCLE-SPECIFIC MICRORNAS IN THE MYOGENIC PROCESSES IN ALS MICE

Malacarne C (1), Marcuzzo S (1), Bonanno S (1), Meroni M (2), Poletti A (2), Galbiati M (2), Mantegazza R (1) and Bernasconi P (1)

(1) Neurology IV –Neuroimmunology and Neuromuscular Diseases Unit, IRCCS Fondazione Istituto Neurologico “Carlo Besta”, Milano, Italy

(2) Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Università degli Studi di Milano, Milano, Italy

 

P.30     CK PROGNOSTIC FACTOR IN FAST/SLOW PROGRESSIVE AMYOTROPHIC LATERAL SCLEROSIS

Pozzilli V (1), Ceccanti M (1) , Di Bari S (1), Fiorini I (1), Fanella G (1), Petrucci A (2), Di Maria G (1) and Inghilleri M (1)

(1) Rare Neuromuscular Diseases Centre, Department of Human Neurosciences, Roma, Italy

(2) Centre for Neuromuscular and Neurological Rare Diseases, San Camillo Forlanini Hospital, Roma, Italy

 

P.31     IN-VIVO PHARMACOLOGICAL BLOCKADE OF MGLU5 RECEPTOR IN THE SOD1G93A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS: A TRANSLATIONAL PERSPECTIVE

Milanese M (1,2), Bonifacino T (1), Provenzano F (1), Rebosio C (1), Ravera S (1), Ferrari F (1), Puliti A (3) and Bonanno G (1,2)

(1) Dept. of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Italy.

(2) Center of Excellence for Biomedical Research, Italy.

(3) Dept. of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, Medical Genetics Unit, University of Genova and Gaslini Institute, Genova, Italy

 

P.32     SODIUM-CALCIUM EXCHANGER AS A DRUGGABLE TARGET IN AMYOTROPHIC LATERAL SCLEROSIS

Anzilotti S (1), Valsecchi V (2), Brancaccio P (2), Secondo A (2), Petrozziello T (2), Cuomo O (2), Annunziato L (1) and Pignataro G (2)

(1) IRCCS SDN, Naples, Italy

(2) Department of Neuroscience, University of Naples “Federico II” Naples, Italy

 

P.33     GENDER-DEPENDENT EFFECT OF P2X7 ANTAGONISM ON MOTOR NEURON DYSFUNCTION IN A MOUSE MODEL OF ALS

Cervetto C (1), Maura G (1) and Marcoli M (1,2)

(1) Department of Pharmacy, University of Genova, Genova, Italy

(2) Centre of Excellence for Biomedical Research CEBR, University of Genova, Genova, Italy

 

P.34     PACAP AND PAC1R ARE DIFFERENTIALLY EXPRESSED IN MOTOR CORTEX OF AMYOTROPHIC LATERAL SCLEROSIS PATIENTS AND SUPPORT SURVIVAL OF IPSC-DERIVED MOTOR NEURONS

Bonaventura G (1), Iemmolo R (1), D’Amico A G (2,3), La Cognata V (1,2,) Costanzo E (4), Zappia M (5), D’Agata V (2), Conforti F L (6), Aronica E (7,8) and Cavallaro S (1)

(1) Institute of Neurological Sciences, Italian National Research Council, Catania, Italy.

(2) Section of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

(3) Department of Human Science and Promotion of Quality of Life, San Raffaele Open University of Rome, Rome, Italy.

(4) Neurology Department, Cannizzaro Hospital of Catania, Catania, Italy.

(5) Department “G. F. Ingrassia”, Section of Neurosciences, University of Catania, Catania, Italy.

(6) Institute of Neurological Sciences, Italian National Research Council, Mangone (CS), Italy.

(7) Department of (Neuro) Pathology, Academic Medical Center, Amsterdam, The Netherlands.

(8) Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands

 

P.35     PROGRESS IN C9-ALS THERAPY: PATIENT SPECIFIC IPSC-DERIVED LINES AS IN VITRO MODEL TO TEST MORPHOLINO OLIGOMERS EFFICACY

Taiana M (1), Bersani (1), Nizzardo M (1), Rinchetti P (1), Barabino S (2), Bresolin N (1), Comi GP (1) and Corti S (1)

(1) Department of Physiopathology and Transplants, University of Milan, IRCCS Ca’ Granda Foundation, Ospedale Maggiore Policlinico Milano

(2) Department of Biotechnology and Biosciences, University of Milano-Bicocca

 

P.36     HETERONYMOUS H REFLEX IN TEMPORAL MUSCLE AS A MEASURE OF HYPEREXCITABILITY AND EARLY DIAGNOSIS IN AMYOTROPHIC LATERAL SCLEROSIS

Fiorini I, Di Bari S, Pozzilli, Fanella G, Libonati L, Barone T, Onesti E, Petrucci A and Inghilleri M

Rare Neuromuscolar Diseases Centre and Department of Neurosciences, University of Rome “La Sapienza”, Rome, Italy

 

P.37     AMYOTROPHIC LATERAL SCLEROSIS (ALS): TELEMEDICINE SYSTEM FOR HOME CARE AND PATIENT MONITORING

Fanella G (1), De Salvo G (2), Frasca V (1), Calamani M (2), Onesti E (1), Ceccanti M (1), Cucchiella C (2), Pozzilli V (1), Fiorini I (1), Goglia M (1) ,Di Bari S (1) and Inghilleri M (1)

(1) Rare Neuromuscular Disease Centre, Department of Human Neuroscience, La Sapienza University, Rome, Italy

(2) Info Solution S.p.A

 

P.38     A POSSIBLE CLUSTER OF ALS IN ITALY

Pupillo E (1), Longinetti E (1,2), Poloni M (1), Bramanti E (3) and Beghi E (1)

(1) IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, Laboratory of Neurological Disease, Milan, Italy

(2) Karolinska Institutet KI Department of Medical Epidemiology and Biostatistics, Solna, Sweden

(3) Italian National Research Council (CNR), Institute of Chemistry of Organo Metallic Compounds (ICCOM)- U.O.S. Pisa, Pisa Italy

 

P.39     SURVIVAL PREDICTION IN MOTOR NEURON DISEASE USING CLINICAL, COGNITIVE AND MULTIMODAL BRAIN MRI DATA

Spinelli E G (1), Agosta F (1), Riva N (2), Basaia S (1), Fontana A (3), Canu E (1), Castelnovo V (1), Falzone Y (2) and Filippi M (1,2)

(1) Neuroimaging Research Unit

(2) Department of Neurology, Institute of Experimental Neurology

(3) Department of Neuroradiology and CERMAC, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

(4) Biostatistics Unit, IRCCS-Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy

 

P.40     FORCED VITAL CAPACITY AND ALS FUNCTIONAL RATING SCALE-REVISED ARE THE BEST PREDICTORS OF PROGRESSION OF DISEASE USING THE KING’S STAGING SYSTEM IN AMYOTROPHIC LATERAL SCLEROSIS

Tarlarini C (1), Lizio A (1), Gerardi F (1), Becchiati S (1), Sansone VA (1,2) and Lunetta C (1)

(1) NEuroMuscular Omnicentre (NeMO), Fondazione Serena Onlus, Milano, Italy

(2) Neurorehabilitation Unit, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

 

P.41     GASTRIC AND ESOPHAGEAL MOTOR ACTIVITY IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS

Di Bari S, Miscioscia A, Onesti A, Gori MC, Inghilleri M, Badiali D, Pallotta N, Pozzili V, Fiorini I and Fanella G

Department of Human Neurosciences, University of Rome “La Sapienza”, Roma, Italy

 

 

 

ARISLA POSTER: “2017 AriSLA Call” winners Projects

 

P.42     AXRIBALS – AXONAL TRANSLATOME IN MOUSE MODELS OF AMYOTROPHIC LATERAL SCLEROSIS

Viero G (1) and Consalez GG (2)

(1) Istitute of Biofisica, CNR Sede secondaria di Trento

(2) University Vita-Salute San Raffaele

 

P.43     HYPERALS – MODULATION OF HYPERMETABOLISM AND HYPEREXCITABILITY AS A STRATEGY TO COUNTERACT DEGENERATION IN ALS

Scaricamazza S (1), Ferri A (1,2,3), Salvatori I (3), Rossi S (2), Giacovazzo G (4), Coccurello R (4,3), Valle C (1,2,3), Carrì MT (1,3)

(1) Department of Biology, University of Rome “Tor Vergata”

(2) Institute of Translational Pharmacology, IFT-CNR Rome

(3) IRCCS Fondazione Santa Lucia Roma

(4) Institute of Neurobiology and Cell Biology, IBCN Rome

 

P.44     TDP-43-STRUCT – PURIFICATION AND STRUCTURE DETERMINATION OF FULL-LENGTH TDP-43

Vivoli M G (1), Ricagno S (2), Corazza A (3) and Chiti F (1)

(1) University of Firenze, Department of experimental and clinical biomedical sciences “Mario Serio”

(2) University of Milan

(3) University of Udine

 

P.45     CIRCRNALS – CIRCULAR RNAS CHARACTERIZATION IN HUMAN MOTOR NEURONS CARRYING ALS -LINKED FUS MUTATIONS

Alfano V (1), Colantoni A (1), DʼAmbra E. (2), De Santis R (1), Rosa A (1), Bozzoni I (1,2), Morlando M (1)

(1) Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome.

(2) Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, Rome.

 

P.46     IRKALS – IMMUNE RESPONSE AGAINST HERV-K IN ALS PATIENTS          

Arru G (2), Deiana GA (1), Sechi E (1) Mariotto S (3), Ferrari S (3), Zanusso G (3), Monaco S (3), Sechi G (1) and Sechi LA (2)

(1) Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.

(2) Department of Biomedical Sciences, University of Sassari, Sassari, Italy

(3) Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

 

P.47     NEVALS – NEUROVASCULAR CROSSTALK IN ALS PATHOGENESIS

Ganesh Bhat, Luis Martins, Giulia De Giovanetti, Aurora Badaloni, Dario Bonanomi

Division of Neuroscience, San Raffaele Hospital, Milan, Italy

 

ARISLA POSTER: ongoing AriSLA Projects (Call 2014, Call 2015, Call 2016)

 

P.48     CARDINALS – CARDIOVASCULAR NEURAL REGULATION IN AMYOTROPHIC LATERAL SCLEROSIS

De Maria B (1), Mora G (1), Marinou K (1), Sideri R (1), Porta A (2,3), Furlan R (4), Dalla Vecchia L (1)

(1) IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy

(2) Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

(3) Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy

(4) Internal Medicine, Humanitas Clinical and Research Center, Rozzano, BIOMETRA Department, University of Milan, Italy

 

P.49     CONNECTALS – NETWORK DEGENERATION IN MOTOR NEURON DISEASES (MND): A STUDY OF THE STRUCTURAL AND FUNCTIONAL CONNECTOMES IN AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MND

Agosta F, Basaia S, Spinelli EG, Riva N, Canu E and Filippi M

INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

P.50     SMALLRNALS –  ALS MOLECULAR THERAPY EXPLOITING INTEGRATED SMALL RNAS AND PROTEOMIC ANALYSIS OF PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELLS

Melzi V (1), Rizzuti M (1), Dioni L (1), Filosa G (2), Calandriello L (1), Biella F (1), Bresolin N (1), Comi GP (1), Barabino S (2), Nizzardo M (1), Corti S (1)

(1) Dino Ferrari Center, Department of Physiopathology and Transplants, IRCCS Cà Granda Foundation, Ospedale Maggiore Policlinico Milano, University of Milan

(2) Department of Biotechnology and Biosciences, University of Milano-Bicocca

 

P.51     ALL_SPEAK – AN AUTOMATIC SPEECH RECOGNITION ANDROID APP FOR ALS PATIENTS

Inuggi A (1), Badino L (2), Mauri I (3), di Nardi C (2), Riva N (3)

(1) Unit of Robotics, Brain and Cognitive Science. Center of Human Technologies. Fondazione Istituto Italiano di Tecnologia (IIT), Genova

(2) Center for Translational Neurophisiology of Speech and Communication. Fondazione Istituto Italiano di Tecnologia (IIT), Ferrara

(3) Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan

 

P.52     ECO-ALS – AUGMENTED ENVIRONMENT FOR CONTROL IN AMYOTROPHIC LATERAL SCLEROSIS

Cozza F (1,2), Bona S (1), Donvito G (1), Vaccari P (3), Lizio A (1), Carraro E (1), Tavazzi S (2), Sansone VA (1,4), Lunetta C (1)

(1) NEuroMuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan

(2) Department of Materials Science  & COMiB, University of Milano-Bicocca, Milan

(3) Auxilia s.r.l, Modena

(4) Department of Biomedical Sciences for Health, University of Milan, Milan

 

P.53     RAP-ALS – RAPAMYCIN (SIROLIMUS) TREATMENT FOR AMYOTROPHIC  LATERAL SCLEROSIS

Zucchi E (1), Cossarizza A (2), Fini N (1), Fasano A (1), Gessani A (1), D’Amico R (3), Caponnetto C (4), Chiò A (5), Dalla Bella E (6), Lunetta C (7), Mazzini L (8), Marinou K (9), Sorarù G (10), De Biasi S (11), Lo Tartaro D (2), Pinti M (11) and Mandrioli J (1)

(1) Department of Neuroscience, St. Agostino-Estense Hospital, Azienda Ospedaliero Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy

(2) Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy

(3) Unit of Statistics, Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria di Modena, Modena, Italy

(4) Department of Neurosciences, Rehabilitatioņ Ophthalmology, Genetics, Mother and Child Disease, Ospedale Policlinico San Martino, Genova, Italy

(5)‘Rita Levi Montalcini’ Department of Neurosciences, ALS Centre, University of Turin and Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy

(6) 3rd Neurology Unit and ALS Centre, IRCCS ‘Carlo Besta’ Neurological Institute, Milan, Italy

(7) NEuroMuscular Omnicenter, Serena Onlus Foundation, Milan, Italy

(8) ALS Centre, Neurologic Clinic, Maggiore della Carità University Hospital, Novara,Italy

(9) ALS Center, ‘Salvatore Maugeri’ Clinical-Scientific Institutes,  Milan, Italy

(10) Department of Neurosciences, University of Padua, Padua, Italy

(11) Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

 

P.54     SCM-ALS – SPINAL CORD METABOLISM IN AMYOTROPHIC LATERAL SCLEROSIS 

Marini C (1,2), Morbelli S (2,3), Cistaro A (4), Campi C (5), Caponnetto C (6,7), Bauckneht M (3), Bellini A (3), Buschiazzo A (3), Calamia I, (3), Beltrametti M C (8), Margotti S (4), Fania (4), Poggi I(6,7), Cabona C (6,7), Capitanio S (2), Piva R (3), Calvo A (9,10), Moglia C (9,10) Canosa A (9,10) Massone A M (11), Nobili F (6,7), Mancardi G (6,7), Chiò A (9,10), Piana M (8,11)and Sambuceti G (2,3)

(1) CNR Institute of Molecular Bioimaging and Physiology (IBFM), Milan, Italy

(2) Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

(3) Department of Health Science, University of Genoa, Genoa, Italy

(4) Positron Emission Tomography Centre IRMET S.p.A., Affidea, Turin, Italy

(5) Department of Medicine–DIMED, Padova University Hospital, Padua, Italy

6) Department of Neuroscience, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

(7) DINOGMI University of Genoa, Genoa, Italy

(8) Department of Mathematics (DIMA), University of Genoa, Genoa, Italy

(9) ALS Center, Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy

(10) AUO Città della Salute e della Scienza, Turin, Italy

(11) SPIN Institute, CNR, Genoa, Italy1CNR Institute of Molecular Bioimaging and Physiology (IBFM), Milan, Italy

 

P.55     DDRNAS – A ROLE FOR DNA DAMAGE RESPONSE RNAS () IN NEURODEGENERATION IN ALS

Gioia U (1), Brandi O (2), Farina S (2), Francia S (1,2) and d’Adda di Fagagna F (1,2)

(1) IFOM – FIRC Institute of Molecular Oncology, Milan, Italy

(2) Institute of Molecular Genetic, CNR, Pavia, Italy

 

P.56     EXOALS – EXOSOMES FROM MESENCHYMAL STEM CELLS AS INNOVATIVE THERAPEUTIC APPROACH FOR ALS

Bonafede R, Scambi I, Schiaffino L, Mariotti R

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

 

P.57     SUMALS – ROLE OF SUMOYLATION IN TDP-43 NUCLEOCYTOPLASMIC TRANSPORT AND AGGREGATION

Maraschi AM (1), Gumina V (1,2), Colombrita C (1), Marcelli C (3), Mompeán M (4), Tinelli C (3), Laurents D (4), Silani V (1,5), Feligioni M (3), Ratti A (1,5)

(1) Dept. Neurology and Lab. Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy

(2) Doctorate School in Molecular and Translational Medicine, Università degli Studi di Milano, Milan.

(3) European Brain Research Institute, Rita-Levi Montalcini Foundation, Rome

(4) Instituto de Química Física “Rocasolano”, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

(5) Department. of Pathophysiology and Transplantation, ‘Dino Ferrari’ Center, Università degli Studi di Milano, Milan